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Safety, Side Effects, and Precautions Known Side Effects BPC-157 TB-500 nasal spray is generally well-tolerated, but potential side effects include: Nasal-Specific Mild nasal irritation or dryness Occasional nosebleeds (rare) Temporary altered sense of smell Nasal congestion Systemic Headaches (uncommon) Dizziness (rare) Fatigue or lethargy (temporary) Localized flushing or warmth Most side effects are mild and resolve with continued use or dosage adjustment